WebFor women not at high fracture risk after 3 to 5 years of BP treatment, a drug holiday of 2 to 3 years can be considered. The suggested approach for long-term BP use is based on limited evidence, only for vertebral fracture reduction, in mostly white postmenopausal women, and does not replace the need for clinical judgment. Webof bisphosphonate-associated osteonecrosis of the jaw is approximately 1 case per 100 000 person-years when bisphosphonates are administered for osteoporosis treatment. • Bisphosphonate drug holidays can be considered for patients who have persisted with bisphosphonate therapy for 3 to 5 years and for those at low risk of fracture.
Managing Osteoporosis in Patients on Long‐Term …
Webbisphosphonates. Drug holidays On 9 September 2011, the US Food and Drug Administration (FDA) held a hearing to review the longterm safety and efficacy of bisphos phonates including alendronate, risedronate, ibandronate and zoledronate. The majority of the advisory committee (17 to 6) voted that labeling for these drugs should further clarify WebSuch holidays are made possible by the very long residence time in bone of bisphosphonates and are considered to be desirable because long-term continuous use of oral bisphosphonates results in increasing rates of atypical femoral fractures (AFF). mario lauzon cpa
Bisphosphonate ‘Drug Holidays’: Are They Beneficial?
WebMost physicians expressed a preference for prescribing weekly or monthly oral bisphosphonates, for both newly diagnosed patients (54.4% and 34.2%, respectively) and long-term users of oral bisphosphonates (40.5% and 36.1%, respectively). Most physicians (23.4% always, 58.9% sometimes) incorporated a drug holiday into their prescribing … WebNov 2, 2024 · A drug holiday allows balancing the long-term benefits with the long-term risks of bisphosphonate treatment. Which Drugs Have Evidence for a Drug Holiday? … WebBisphosphonates can accumulate in bone, so after a period of treatment, lower risk patients may be offered a period off drug therapy. ... Raloxifene Oral, daily Spine only No limit Alendronate Oral, weekly Spine, hip, nonvertebral Consider a ‘‘drug holiday’’ after 5 years Risedronate Oral, weekly or monthly Spine, hip, nonvertebral ... danaher investor presentation