Ferroptosis and hcc

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August undefined, 2024

WebFerroptosis is a novel type of regulatory cell death due to abnormal accumulation of lipid reactive oxygen species and iron overload. 4 Inducing ferroptosis of tumor cells has … WebFeb 26, 2024 · Ferroptosis is a form of programmed cell death, distinct from apoptosis, that was identified in 2012. The process is driven by the iron-dependent oxidative …

Role of ferroptosis in hepatocellular carcinoma - PubMed

WebAbstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a … WebAbstract Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor prognosis, and novel treatment strategies are urgently needed. Mitochondria are key regulators of cellular h... townhouses for sale in maple ontario

Ferroptosis: molecular mechanisms and health implications

WebSep 10, 2024 · Ferroptosis is a novel cell program that is involved in several diseases, such as cancer. Heat shock protein beta 1 (HSPB1) is a major component of heat shock proteins. A recent study showed that HSPB1 could be a new therapeutic target for colorectal cancer with 5-fluorouracil-acquired resistance. WebTSPO is highly expressed in HCC and associated with poor prognosis. Gain- and loss-of-function experiments present that TSPO promotes HCC cell growth, migration, and … WebLncRNAs are also regulators of ferroptosis in HCC, but their action has not been clarified [465,466]. Recently, signature models using lncRNAs and ferroptosis were established, … townhouses for sale in maple grove mn

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib

Ferroptosis: From Basic Research to Clinical Therapeutics in ...

WebApr 10, 2024 · Treatments to prevent the progression of fibrosis to HCC have not been pharmacologically successful and the causes of fibrotic liver disease remain to be elucidated . Ferroptosis has been linked to liver fibrosis and excess iron is a known risk factor and this has been directly demonstrated [10, 11]. WebSep 20, 2024 · A study has shown that deletion of CP can promote the ferroptosis of HCC cells caused by erastin and RSL3 and can lead to the accumulation of intracellular … townhouses for sale in manhattan ilWebFerroptosis is a new form of cell death that results from iron accumulation and lipid peroxidation in cells. It involves depletion in the antioxidant enzymes resulting in lipid … townhouses for sale in maple glen pa

"WebApr 4, 2024 · Several studies aimed to construct effective predictive models in HCC previously, including deep learning-based multi-omics model, radiomics model and gene signature models [2–6]. Studies have proved that m6A-related genes, ferroptosis-related genes, and aging-related genes were all associated with cancer prognosis [7, 8]. … " - Ferroptosis and hcc

Ferroptosis and hcc

Ferroptosis-related lncRNA signature predicts the prognosis and …

WebNoteworthy, we retrospectively analyzed the effect of sorafenib on HSC ferroptosis in advanced fibrotic patients with hepatocellular carcinoma receiving sorafenib monotherapy. Attractively, ELAVL1 upregulation, ferritinophagy activation, and ferroptosis induction occurred in primary human HSCs from the collected human liver tissue. WebMar 24, 2024 · To verify the influence of miR-21-5p on ferroptosis and EMT in HCC cells, we transfected MHCC97L and HepG2 cells with miR-21-5p mimic and added erastin, an ferroptosis inducer. The Western blot results showed that the levels of GPX4, FTH1, and x CT were markedly elevated after transfection of the miR-21-5p mimic, while the level of …

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http://lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2024.04.032 WebAug 16, 2024 · In this paper, we analyze the ferroptosis-inducing drugs and experimental agents that have been used in the last 5 years in the treatment of HCC. We summarize four different key molecular mechanisms that induce ferroptosis, i.e., system xc-/GSH/GPX4, iron metabolism, p53 and lipid peroxidation.

WebFeb 28, 2024 · In this review, we discuss the regulatory network of ferroptosis, describe the crosstalk between ferroptosis and HCC-related signaling pathways, and elucidate the potential role of ferroptosis in various treatment modalities for HCC, such as systemic therapy, radiotherapy, immunotherapy, interventional therapy and nanotherapy, and … WebApr 4, 2024 · Apoptosis, Pyroptosis, and Ferroptosis Conspiringly Induce Immunosuppressive Hepatocellular Carcinoma Microenvironment and γδ T-Cell Imbalance Front Immunol. 2024 Apr 4;13:845974. doi: 10.3389/fimmu.2024.845974. eCollection …

WebHu-antigen R (HuR) is a post-transcriptional regulator that belongs to the embryonic lethal abnormal vision Drosophila-like family (ELAV). HuR regulates the stability, translation, subcellular localization, and degradation of several target mRNAs, which are implicated in carcinogenesis and could affect therapeutic options. HuR protein is consistently highly … WebAug 1, 2024 · Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factors, and discuss the...

WebOct 28, 2024 · In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the … townhouses for sale in manassas vaWebApr 13, 2024 · 3.The review briefly mentions the role of ferroptosis in HCC, but it does not provide a comprehensive explanation of this regulated cell death mechanism. The section on ferroptosis has been extensively revised and all described mechanisms have been added in the revised figure. townhouses for sale in markhamWebFeb 14, 2024 · Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence and that abundant ferroptosis in cells can inhibit tumor progression. townhouses for sale in maple ridge bcWebApr 4, 2024 · Hepatocellular carcinoma (HCC) is highly malignant and prone to metastasize due to the heterogeneous and immunosuppressive tumor microenvironment (TME). … townhouses for sale in mankato mnWebSep 9, 2024 · Background Ferroptosis is a novel form of regulated cell death involved in tumor progression. The role of ferroptosis-related lncRNAs in hepatocellular carcinoma (HCC) remains unclear.... townhouses for sale in mawson lakes saWebApr 30, 2024 · Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, has been shown to induce ferroptosis in hepatocellular carcinoma (HCC). However, some hepatoma cell lines are less sensitive to sorafenib-induced ferroptotic cell death. Glutathione S-transferase zeta 1 (GSTZ1), an enzyme in the catabolism of phenylalanine ... townhouses for sale in marlborough ma townhouses for sale in maryville tn