Pherexa
WebMay 20, 2016 · PHEREXA: A phase III study of trastuzumab (H) + capecitabine (X) ± pertuzumab (P) for patients (pts) who progressed during/after one line of H-based therapy … WebJun 9, 2016 · PHEREXA: No PFS Benefit of Adding Pertuzumab to Trastuzumab + Capecitabine in HER2+ MBC Progressing on or After Trastuzumab-Based Therapy …
Pherexa
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WebMay 4, 2024 · The PHEREXA trial, published in the current issue of JCO, investigated the addition of pertuzumab to trastuzumab plus capecitabine in the second-line metastatic setting after prior therapy with chemotherapy and trastuzumab.The primary endpoint, improved PFS, was not met from a statistical sense; the median PFS improvement from 9 … WebDec 22, 2024 · The drugs pertuzumab (Perjeta) and trastuzumab (Herceptin) target HER2-positive cancer cells. Pertuzumab in combination with trastuzumab and chemotherapy (taxane chemotherapy is preferred) can slow the growth of HER2-positive metastatic breast cancer and increase survival better than trastuzumab and chemotherapy alone [3].
WebOct 1, 2012 · Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate incorporating the human epidermal growth factor receptor 2 (HER2)–targeted antitumor properties of trastuzumab with the cytotoxic... WebJul 25, 2016 · PHEREXA: Benefit for Second-Line Pertuzumab Questionable. By Caroline Helwick July 25, 2016. Advertisement. We observed an 8-month increase in median overall survival with pertuzumab, to 36.1 months. Statistical significance for overall survival cannot be claimed due to the hierarchical testing. However, the magnitude of benefit is in keeping …
WebDec 4, 2009 · A Multicenter Randomized Phase III Study to Compare the Combination Trastuzumab and Capecitabine, With or Without Pertuzumab, in Patients With HER2 … WebApr 22, 2024 · However, within the PHEREXA phase III trial of BC patients receiving pertuzumab in addition to trastuzumab and capecitabine during or after progression upon …
WebOct 15, 2015 · In my opinion, of greatest interest will be the upcoming data of these two monoclonal antibodies in combination with endocrine therapy, and the results of the PHEREXA trial, a randomized study that will define the role of pertuzumab with trastuzumab and capecitabine in patients progressing on trastuzumab-based therapy.
WebAs commented before, the use of trastuzumab and pertuzumab in trastuzumab-resistant patients has been explored in phase II studies. 17,18,24 Based on the promising activity of … bmw motorcycle dealers coloradoWebWe present exploratory efficacy results from pts treated with T-DM1 any time after P from 2 phase III studies: CLEOPATRA and PHEREXA. Methods: CLEOPATRA (NCT00567190) and PHEREXA (NCT01026142) are randomized, 2-arm trials evaluating P … bmw motorcycle dealers cape townclickcounter ioWebJun 23, 2016 · PHEREXA Trial in HER2+ Disease Jun 23, 2016 Transcript:Adam M. Brufsky, MD, PhD: Let’s move on to a few more HER2 topics before we get to tyrosine kinase … click counter keep trackWebMay 30, 2024 · We present exploratory efficacy results from pts treated with T-DM1 any time after P from 2 phase III studies: CLEOPATRA and PHEREXA. Methods: CLEOPATRA (NCT00567190) and PHEREXA (NCT01026142) are randomized, 2-arm trials evaluating P-based regimens for HER2+ MBC. click counter leftWebMar 15, 2013 · The role of pertuzumab in the second-line setting will be addressed by results of the PHEREXA trial. The continuation of HER2 blockade remains an important component of therapy at disease progression, and therapy with lapatinib or novel agents available through clinical trials should be considered. Data from the EMILIA trial showed that T … bmw motorcycle dealership indianapolisWebMonthly Plenary Series . Abstracts & Presentations bmw motorcycle dealership for sale