WebbIt is concluded that TOF-SIMS at the present state is a powerful tool in imaging of ions and organic compounds at a MW up to ≈ 1,000 in biological tissues. TOF-SIMS has a potential to provide very significant information for the understanding of physiological functions and pathological processes in biomedical research. Webb17 okt. 2014 · Typical TOF-SIMS imaging of lipids from a complete sagittal rat brain section is provided in Fig. 1, as well as a close-up TOF-SIMS analysis of a 500 μm × 500 …
Confirmation of Interlayer Sulfidization of Malachite by TOF-SIMS …
WebbAbstract: The use of high-resolution, imaging TOF-SIMS is described and examples are made to demonstrate the application of the method in medical research. Cytochemistry by TOF-SIMS is shown by localization of diacylglycerol (DG) in cryostat sections of hyaline cartilage and by localization of corticosterone in cryostat sections of the adrenal gland … WebbIn vivo imaging of reactive small molecule metabolites with high spatial resolution and specificity could give clues to understanding pathophysiology of various diseases. We herein applied time of fl make a terms and conditions page
(PDF) GCIB-ToF-SIMS high resolution imaging of ... - ResearchGate
WebbSecondary ion mass spectrometry (SIMS) has been increasingly recognized as a powerful technique for visualizing molecular architectures in the fields of neurobiology and cell biology. There are two main platforms of SIMS, namely ToF-SIMS and nanoscale SIMS (nanoSIMS), which are capable of imaging different t SIMS for Biological Applications … Webb25 sep. 2024 · Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical technique rapidly expanding in use in biological studies. This technique is based on high spatial resolution (50–100 nm), high surface sensitivity (1–2 nm top-layer), and statistical analytic power. In mass spectrometry imaging (MSI), sample preparation is a … Webb12 apr. 2024 · Prior to ToF-SIMS experiments, frozen GBM sections were freeze-dried and then analyzed with Bi 3 + primary ion gun under the vacuum condition. Thereafter, the distribution of different lipids from ToF-SIMS images was correlated with the same histological regions from the H&E staining image to obtain useful information of GBM … make a tetherball pole