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Topbp1 phf8

Web26. feb 2024 · CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication Authors Haihua Feng 1 , Jingchen Lu 1 2 , Xiaotian Song 1 , … Genomic stability following DNA damage depends on the coordination of cell cycle checkpoint control and proper DNA repair. ATR (ataxia telangiectasia mutated- and Rad3-related) … Zobraziť viac Human TopBP1 is a key scaffold protein that can interact with many other proteins and play essential roles in a diverse range of cellular pathways, including DNA replication … Zobraziť viac We would like to thank all our colleagues in the Gong laboratory for insightful discussion and technical assistance. We want to thank Dr … Zobraziť viac

Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific

WebATR activation requires the ATR activator, topoisomerase II?-binding protein 1 (TopBP1). However, the underlying mechanism of TopBP1 regulation and how its regulation affects DNA replication remain unknown. Here, we report a specific interaction between TopBP1 and the histone demethylase PHF8. ... Read More Show Mesh Terms Nucleic Acids Res Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from Phf8 grow slowly and … m-1 2021 なんj https://houseofshopllc.com

TOPBP1 - Wikipedia

http://tjmuch.xuezheku.com/Document/Detail/03B2F8F72127E5C382F608838429034B.html Web27. okt 2024 · Mammalian TopBP1 has been reported to be involved in a variety of different cellular processes, such as regulating the DNA replication checkpoint as well as the mitotic checkpoint and its progression. Web27. máj 2024 · TOPBP1含有多组成对出现的BRCT（BRCA1 C-terminal）结构域，它们负责识别不同磷酸化形式的配体蛋白，决定了TOPBP1在复制起始或复制压力应答中的特异性工作模式。 然而，在HR倾向性的DSBs染色质区域，TOPBP1是如何被募集的尚不清楚。 作者发现HTATSF1（HIV Tat-specific factor 1）在复制活跃细胞中高表达，是S期TOPBP1相互作用 … agc seimi chemical co

PHF8 - TOPBP1 Interaction Summary BioGRID

Category:(PDF) CK2 kinase-mediated PHF8 phosphorylation controls …

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Topbp1 phf8

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Web21. júl 2024 · The SLX1-SLX4 structure-specific endonuclease complex is involved in processing diverse DNA damage intermediates, including resolution of Holliday junctions, collapse of stalled replication forks and removal of DNA flaps. The nuclease subunit SLX1 is inactive on its own, but become activated upon bi … Web接下来我们发现PHF8和TopBP1在体内、体外存在相互作用,并且PHF8是通过其C端的22个保守的氨基酸与TopBP1的BRCT 7+8结构域相互作用。 PHF8负责与TopBP1相互作用的22aa以及它的去甲基化酶活性都能影响ATR信号的活化,并且PHF8与TopBP1相互作用的部分以及它的去甲基化酶活性也影响了TopBP1的募集;在临床组织样本分析中,我们发现PHF8 …

Topbp1 phf8

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Web1. dec 2024 · Clearly further work will be required to fully delineate the role of PHF8 in the complex functions of TOPBP1. Although not an enzyme itself, but rather a regulator of one - the protein phosphatase PP2A inhibitor CIP2A has recently been characterised as an essential TOPBP1 interactor [69], [70]. WebMechanistically, PHF8 interacts with and demethylates TOPBP1 (DNA topoisomerase 2-binding protein 1), an essential allosteric activator of ATR, under unperturbed conditions, but replication stress results in PHF8 phosphorylation and dissociation from TOPBP1.

Web28. jan 2024 · Interaction between TopBP1 and PHF8 is cell-cycle and phosphorylation dependent. ( A) The interaction between TopBP1 and PHF8 is cell-cycle dependent. HeLa … Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 demethylation is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from …

WebTOPBP1. DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. [5] [6] [7] TOPBP1 was first identified as a … WebBioGRID Interaction 2973250 Between TOPBP1 And PHF8. Toggle navigation. Bio GRID 4.4

Web3. okt 2024 · PHF8 is phosphorylated by CK2, which regulates binding of PHF8 to TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and …

Web23. apr 2024 · Reliable and accurate glucose detection in biological samples is of great importance in clinical diagnosis and medical research. Chemical probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has … m 1 2022 動画 フルhttp://tjmuch.xuezheku.com/Document/Detail/3CD51036AB65765EB09BDC52F8092BE4.html m1 2019 動画フルWebPHF8 regulates the TopBP1 protein level through UBR5-mediated ubiquitination. (A) TopBP1 protein level decreased in PHF8 KD cells. MCF-7/MCF-7 PHF8 KD and MDA-MB-231/MDA … m12コネクタWeb6. dec 2024 · Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/beta-catenin signaling pathway. Disrupting PHF8 … agc si techWebHere, we showed PHF8-promoted TOPBP1 demethylation is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from Phf8 knockout mice grow slowly and exhibit higher level of K118me1, lower … m-1 2018 準決勝 レポWebPHF8 is phosphorylated by CK2, which regulates binding of PHF8 to TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and degradation … agc soverso 47240Web4. nov 2024 · PHF8 is phosphorylated by CK2, which regulates binding of PHF8 to TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and … m12 p1.5 ボルト 規格