Ultrafine anaphase bridges
Web2 Mar 2024 · More information: Nannan Kong et al, RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1, Cell Reports (2024). DOI: … Web25 Sep 2024 · Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at …
Ultrafine anaphase bridges
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WebUltrafine anaphase bridges (UFBs) result from a defect in sister chromatid segregation during anaphase. They arise from particular DNA structures, mostly generated at specific … WebPreviously, anaphase bridges were presumed to be a rare occurrence, however, recent evidence has shown that in most mitosis ultrafine anaphase bridges (UFBs) are …
WebWe show that loss of the structure-selective endonuclease GEN1 reduces CFS expression, leading to defects in MiDAS, ultrafine anaphase bridge formation, and DNA damage in the … Web4 Sep 2024 · Anaphase bridges originate from unresolved SCIs. DNA intertwines are usually classified based on their molecular structure, which reflects their origin (Figure 1). Three …
WebAbout. I am a postdoctoral fellow in the Cappell lab at the NIH, Bethesda, US. We are working on the cell cycle with special interest in regulators governing the induction of senescence. … Web22 Aug 2013 · The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFBs) in mitosis alongside a complex of DNA repair proteins, including the Bloom’s syndrome protein (BLM). However, very little is known about the function of PICH or how it is recruited to UFBs. Using a combination of microfluidics, fluorescence …
WebUltrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late …
Web12 Nov 2024 · A proposed model of the assembly of the ultra-fine DNA bridge (UFB)-associated factors on UFB structures. (Top) Schematic representation of the formation of … now music collectionWeb1 Jan 2011 · BLM-defective cells display a higher frequency of anaphase bridges and lagging chromatin than isogenic control cells that express the BLM protein. In normal cells undergoing mitosis, BLM protein localises to anaphase bridges. Using BLM staining as a marker, it is possible to identify a class of ultrafine DNA bridges. nicole renee inlowWeb30 Aug 2024 · Failure to process joint DNA molecules in mitosis leads to persistent entangling of sister chromatids, generating ultrafine DNA bridges (UFBs) as cells … nicole rehab addict sonWeb20 Sep 2024 · FX cells treated with 5-fluoro-2′-deoxyuridine (FdU), a direct inhibitor of thymidylate synthase, show an increase not only in the expression of the fragile site, but … nicole remy and daniel bochicchioWeb26 Aug 2024 · Ultrafine anaphase bridges (UFBs) result from a defect in sister chromatid segregation during anaphase. They arise from particular DNA structures, mostly … nicole rehab addict glassesWeb25 Jul 2024 · No replication: ultrafine anaphase bridges. A quite different outcome for CFSs is seen if DNA replication is not completed in M phase. The persistence of a replication intermediate and, probably ... now music - free music appWebNew insights into the formation and resolution of ultrafine anaphase bridges. Semin Cell Dev Biol (2011), 22(8): 906-12. Chan KL, Hickson ID. On the origins of ultra-fine anaphase bridges. Cell Cycle (2009), 8(19): 3065-6. Cheok CF, Bachrati CZ, Chan KL, Ralf C, Wu L, Hickson ID. Roles of the Bloom's syndrome helicase in the maintenance of ... now music freeview